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KMID : 1189420170300040025
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Journal of Korean Oriental Medical Ophthalmology & Otolaryngology & Dermatology
2017 Volume.30 No. 4 p.25 ~ p.36
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Effects of Capsosiphon Fulvescens Extract on Contact Dermatitis in NC/Nga Mice
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Eom Ye-Jin
Hong Chul-Hee
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Abstract
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Objectives : The aim of this study is to report the effect of Capsosiphon fulvescens(Maesangi) extract(MSE) on contact dermatitis(CD).
Methods : CD induced by Dermatophagoides farinae body(Dfb) in NC/Nga mice. 4% sodium dodecyl sulfate(SDS) 150㎕ and Dfb(10㎎/㎖) ointment 100㎎ were topically treated twice a week for four weeks. MSE 200 ㎎/㎏ was topically treated every 4weeks. Every week, we examined the skin lesions, weight of spleen and lymph node, epidermal thickness, production of Tumor necrosis factoralpha(TNFα) and interleukin6(IL6).
Results : MSE reduced features of Dfb-induced skin lesions, weight of spleen and production of TNFα. MSE significantly reduced weight of lymph node, epidermal thickness, number of mast cells and production of IL6.
Conclusions : MSE may have a potential therapeutic effects for CD by suppressing allergic inflammation.
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KEYWORD
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Capsosiphon fulvescens , Contact Dermatitis(CD) , NC/Nga mice
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